Androgen deprivation therapy may also prolong the QT QTc interval. This risk may be more clinically significant with long acting beta agonists as compared to short acting beta agonists. Oxaliplatin: Major Monitor ECGs for QT prolongation and monitor electrolytes in patients receiving oxaliplatin concomitantly with leuprolide; correct reochert abnormalities prior to administration of oxaliplatin.
Prolongation of the QT interval and ventricular arrhythmias including fatal torsade de pointes TdP have been reported with oxaliplatin use in postmarketing experience. Androgen deprivation therapy i. leuprolide may also prolong the QT QTc interval.